Symbol: Name: ID: |
C12orf5 chromosome 12 open reading frame 5 GFS:1664 |
Gene name: | C12orf5 |
Chromosome: | 12p13.32 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TIGAR |
Name Aliases: | TP53-induced glycolysis and apoptosis regulator |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2442752 | Rat Genome Database ID: | RGD:1560038 |
HGNC ID: | HGNC:1185 | RefSeq IDs: | NM_020375 |
Entrez Gene ID: | 57103 | Ensembl Gene ID: | ENSG00000078237 |
VEGA IDs: | UniProt ID: | Q9NQ88 | |
UCSC ID: | uc001qmp.2 | OMIM ID: | 610775 |
Pubmed: | PMID16140933 PMID 16839880 PMID 18945750 PMID 19713938 | ||
CCDS IDs: | CCDSCCDS8525.1 |
Probable fructose-2,6-bisphosphatase TIGAR is an enzyme that in humans is encoded by the C12orf5 gene. This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq].
Probable fructose-biphosphatase. Lowers cellular levels of fructose 2,6-bisphosphate. Protects cells against reactive oxygen species and against apoptosis induced by p53/TP53.
Products for C12orf5 gene
Catalog | Product Name | Application | Company |
GFS:E01664 | chromosome 12 open reading frame 5; ELISA kit | ELISA | n/a |
GFS:A01664 | chromosome 12 open reading frame 5; Anti | ANTIBODIES | n/a |
GFS:P01664 | chromosome 12 open reading frame 5; Protien | Protien | n/a |