Symbol: Name: ID: |
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 GFS:5124 |
Gene name: | CHST8 |
Chromosome: | 19q13.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | GALNAC-4-ST1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1916197 | Rat Genome Database ID: | RGD:1308979 |
HGNC ID: | HGNC:15993 | RefSeq IDs: | NM_001127895 |
Entrez Gene ID: | 64377 | Ensembl Gene ID: | ENSG00000124302 |
VEGA IDs: | UniProt ID: | Q9H2A9 | |
UCSC ID: | uc002nut.3 | OMIM ID: | 610190 |
Pubmed: | PMID10988300 PMID 11001942 | ||
CCDS IDs: | CCDSCCDS12433.1 |
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is predominantly expressed in the pituitary gland, and is localized to the golgi membrane. This protein catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. It is responsible for sulfation of GalNAc on luteinizing hormone (LH), which is required for production of the sex hormones. Mice lacking this enzyme, exhibit increased levels of circulating LH, and precocious sexual maturation of both male and female mice. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011].
Function: Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin.
Products for CHST8 gene
Catalog | Product Name | Application | Company |
GFS:E05124 | carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8; ELISA kit | ELISA | n/a |
GFS:A05124 | carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8; Anti | ANTIBODIES | n/a |
GFS:P05124 | carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8; Protien | Protien | n/a |