Symbol: Name: ID: |
CAMK2A calcium/calmodulin-dependent protein kinase II alpha GFS:3901 |
Gene name: | CAMK2A |
Chromosome: | 5 |
Previous Symbols: | CAMKA |
Previous Names: | calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha |
Aliases: | KIAA0968, CaMKIINalpha |
Name Aliases: | CaM-kinase II alpha chain, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88256 | Rat Genome Database ID: | RGD:2261 |
HGNC ID: | HGNC:1460 | RefSeq IDs: | NM_015981 |
Entrez Gene ID: | 815 | Ensembl Gene ID: | ENSG00000070808 |
VEGA IDs: | OTTHUMG00000134281 | UniProt ID: | Q9UQM7 |
UCSC ID: | uc003lrt.2 | OMIM ID: | 114078 |
Pubmed: | PMID10231032 PMID 3475713 | ||
CCDS IDs: | CCDSCCDS43386.1 CCDS CCDS43387.1 |
Calcium/calmodulin-dependent protein kinase type II alpha chain is an enzyme that in humans is encoded by the CAMK2A gene.
The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008].
Function: CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).
Products for CAMK2A gene
Catalog | Product Name | Application | Company |
GFS:E03901 | calcium/calmodulin-dependent protein kinase II alpha; ELISA kit | ELISA | n/a |
GFS:A03901 | calcium/calmodulin-dependent protein kinase II alpha; Anti | ANTIBODIES | n/a |
GFS:P03901 | calcium/calmodulin-dependent protein kinase II alpha; Protien | Protien | n/a |