Symbol: Name: ID: |
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta GFS:3984 |
Gene name: | CAMKK2 |
Chromosome: | 12q24.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CAMKK, KIAA0787, CAMKKB, MGC15254 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2444812 | Rat Genome Database ID: | RGD:620092 |
HGNC ID: | HGNC:1470 | RefSeq IDs: | NM_006549 |
Entrez Gene ID: | 10645 | Ensembl Gene ID: | ENSG00000110931 |
VEGA IDs: | UniProt ID: | Q96RR4 | |
UCSC ID: | uc001tzv.2 | OMIM ID: | |
Pubmed: | PMID9662074 | ||
CCDS IDs: | CCDSCCDS9216.1 CCDS CCDS9217.1 CCDS CCDS9218.1 CCDS CCDS9219.1 CCDS CCDS44999.1 |
Calcium/calmodulin-dependent protein kinase kinase 2 is an enzyme that in humans is encoded by the CAMKK2 gene.
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Seven transcript variants encoding six distinct isoforms have been identified for this gene. Additional splice variants have been described but their full-length nature has not been determined. The identified isoforms exhibit a distinct ability to undergo autophosphorylation and to phosphorylate the downstream kinases. [provided by RefSeq, Jul 2008].
Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Seems to be involved in hippocampal activation of CREB1 (By similarity).
Products for CAMKK2 gene
Catalog | Product Name | Application | Company |
GFS:E03984 | calcium/calmodulin-dependent protein kinase kinase 2, beta; ELISA kit | ELISA | n/a |
GFS:A03984 | calcium/calmodulin-dependent protein kinase kinase 2, beta; Anti | ANTIBODIES | n/a |
GFS:P03984 | calcium/calmodulin-dependent protein kinase kinase 2, beta; Protien | Protien | n/a |