Symbol: Name: ID: |
CDH8 cadherin 8, type 2 GFS:6614 |
Gene name: | CDH8 |
Chromosome: | 16q22.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:107434 | Rat Genome Database ID: | RGD:69286 |
HGNC ID: | HGNC:1767 | RefSeq IDs: | NM_001796 |
Entrez Gene ID: | 1006 | Ensembl Gene ID: | ENSG00000150394 |
VEGA IDs: | OTTHUMG00000137493 | UniProt ID: | P55286 |
UCSC ID: | uc002eog.1 | OMIM ID: | 603008 |
Pubmed: | PMID9615235 PMID 2059658 | ||
CCDS IDs: | CCDSCCDS10802.1 |
Cadherin-8 is a protein that in humans is encoded by the CDH8 gene.
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Products for CDH8 gene
Catalog | Product Name | Application | Company |
GFS:E06614 | cadherin 8, type 2; ELISA kit | ELISA | n/a |
GFS:A06614 | cadherin 8, type 2; Anti | ANTIBODIES | n/a |
GFS:P06614 | cadherin 8, type 2; Protien | Protien | n/a |