Symbol: Name: ID: |
CDH4 cadherin 4, type 1, R-cadherin (retinal) GFS:6588 |
Gene name: | CDH4 |
Chromosome: | 20q13.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | R-Cadherin |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:99218 | Rat Genome Database ID: | RGD:1586170 |
HGNC ID: | HGNC:1763 | RefSeq IDs: | NM_001794 |
Entrez Gene ID: | 1002 | Ensembl Gene ID: | ENSG00000179242 |
VEGA IDs: | OTTHUMG00000032890 | UniProt ID: | P55283 |
UCSC ID: | uc002ybn.1 | OMIM ID: | 603006 |
Pubmed: | PMID10191097 PMID 10516427 | ||
CCDS IDs: | CCDSCCDS13488.1 |
Cadherin-4 is a protein that in humans is encoded by the CDH4 gene.
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.
Products for CDH4 gene
Catalog | Product Name | Application | Company |
GFS:E06588 | cadherin 4, type 1, R-cadherin (retinal); ELISA kit | ELISA | n/a |
GFS:A06588 | cadherin 4, type 1, R-cadherin (retinal); Anti | ANTIBODIES | n/a |
GFS:P06588 | cadherin 4, type 1, R-cadherin (retinal); Protien | Protien | n/a |