Symbol: Name: ID: |
BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) GFS:1369 |
Gene name: | BUB3 |
Chromosome: | 10q24 |
Previous Symbols: | |
Previous Names: | BUB3 (budding uninhibited by benzimidazoles 3, yeast) homolog |
Aliases: | BUB3L |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1343463 | Rat Genome Database ID: | |
HGNC ID: | HGNC:1151 | RefSeq IDs: | NM_001007793 |
Entrez Gene ID: | 9184 | Ensembl Gene ID: | ENSG00000154473 |
VEGA IDs: | OTTHUMG00000019197 | UniProt ID: | O43684 |
UCSC ID: | uc001lhe.2 | OMIM ID: | 603719 |
Pubmed: | PMID9660858 | ||
CCDS IDs: | CCDSCCDS7635.1 CCDS CCDS31306.1 |
Mitotic checkpoint protein BUB3 is a protein that in humans is encoded by the BUB3 gene This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].
Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.
Products for BUB3 gene
Catalog | Product Name | Application | Company |
GFS:E01369 | budding uninhibited by benzimidazoles 3 homolog (yeast); ELISA kit | ELISA | n/a |
GFS:A01369 | budding uninhibited by benzimidazoles 3 homolog (yeast); Anti | ANTIBODIES | n/a |
GFS:P01369 | budding uninhibited by benzimidazoles 3 homolog (yeast); Protien | Protien | n/a |