Symbol: Name: ID: |
BUB1B budding uninhibited by benzimidazoles 1 homolog beta (yeast) GFS:1350 |
Gene name: | BUB1B |
Chromosome: | 15q15 |
Previous Symbols: | |
Previous Names: | budding uninhibited by benzimidazoles 1 (yeast homolog), beta |
Aliases: | BUBR1, MAD3L, Bub1A, SSK1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1333889 | Rat Genome Database ID: | RGD:619791 |
HGNC ID: | HGNC:1149 | RefSeq IDs: | NM_001211 |
Entrez Gene ID: | 701 | Ensembl Gene ID: | ENSG00000156970 |
VEGA IDs: | OTTHUMG00000129877 | UniProt ID: | O60566 |
UCSC ID: | uc001zkx.3 | OMIM ID: | 602860 |
Pubmed: | PMID9889005 | ||
CCDS IDs: | CCDSCCDS10053.1 |
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta is an enzyme that in humans is encoded by the BUB1B gene. This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.
Products for BUB1B gene
Catalog | Product Name | Application | Company |
GFS:E01350 | budding uninhibited by benzimidazoles 1 homolog beta (yeast); ELISA kit | ELISA | n/a |
GFS:A01350 | budding uninhibited by benzimidazoles 1 homolog beta (yeast); Anti | ANTIBODIES | n/a |
GFS:P01350 | budding uninhibited by benzimidazoles 1 homolog beta (yeast); Protien | Protien | n/a |