Symbol: Name: ID: |
BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) GFS:1346 |
Gene name: | BUB1 |
Chromosome: | 2p11-q21 |
Previous Symbols: | BUB1L |
Previous Names: | budding uninhibited by benzimidazoles 1 (yeast homolog) |
Aliases: | hBUB1, BUB1A |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1100510 | Rat Genome Database ID: | RGD:1311707 |
HGNC ID: | HGNC:1148 | RefSeq IDs: | NM_004336 |
Entrez Gene ID: | 699 | Ensembl Gene ID: | ENSG00000169679 |
VEGA IDs: | OTTHUMG00000153638 | UniProt ID: | O43683 |
UCSC ID: | uc002tgc.2 | OMIM ID: | 602452 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS33273.1 |
Mitotic checkpoint serine/threonine-protein kinase BUB1 also known as BUB1 (budding uninhibited by benzimidazoles 1) is an enzyme that in humans is encoded by the BUB1 gene.
Bub1 is a serine/threonine protein kinase first identified in genetic screens of Saccharomyces cerevisiae.The protein is bound to kinetochores and plays a key role in the establishment of the mitotic spindle checkpoint and chromosome congression. The mitotic checkpoint kinase is evolutionary conserved in organisms as diverse as Saccharomyces cerevisiae and humans. Loss-of-function mutations or absence of Bub1 has been reported to result in aneuploidy, chromosomal instability (CIN) and premature senescence.
This gene encodes a kinase involved in spindle checkpoint function. The kinase functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint. Mutations in this gene have been associated with aneuploidy and several forms of cancer. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Products for BUB1 gene
Catalog | Product Name | Application | Company |
GFS:E01346 | budding uninhibited by benzimidazoles 1 homolog (yeast); ELISA kit | ELISA | n/a |
GFS:A01346 | budding uninhibited by benzimidazoles 1 homolog (yeast); Anti | ANTIBODIES | n/a |
GFS:P01346 | budding uninhibited by benzimidazoles 1 homolog (yeast); Protien | Protien | n/a |