Symbol: Name: ID: |
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 GFS:4680 |
Gene name: | ALDH8A1 |
Chromosome: | 6q24.1-q25.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | ALDH12 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2653900 | Rat Genome Database ID: | RGD:1590218 |
HGNC ID: | HGNC:15471 | RefSeq IDs: | NM_001193480 |
Entrez Gene ID: | 64577 | Ensembl Gene ID: | ENSG00000118514 |
VEGA IDs: | OTTHUMG00000015623 | UniProt ID: | Q9H2A2 |
UCSC ID: | uc003qew.2 | OMIM ID: | 606467 |
Pubmed: | PMID11007799 | ||
CCDS IDs: | CCDSCCDS5171.1 CCDS CCDS5172.1 |
This protein belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Three transcript variants encoding distinct protein isoforms have been identified for this gene. [provided by RefSeq, Jul 2010].
Function: Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro).
Products for ALDH8A1 gene
Catalog | Product Name | Application | Company |
GFS:E04680 | aldehyde dehydrogenase 8 family, member A1; ELISA kit | ELISA | n/a |
GFS:A04680 | aldehyde dehydrogenase 8 family, member A1; Anti | ANTIBODIES | n/a |
GFS:P04680 | aldehyde dehydrogenase 8 family, member A1; Protien | Protien | n/a |