Symbol: Name: ID: |
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 GFS:4681 |
Gene name: | ALDH1A2 |
Chromosome: | 15q21.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | RALDH2 |
Name Aliases: | retinaldehyde dehydrogenase 2 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:107928 | Rat Genome Database ID: | RGD:620250 |
HGNC ID: | HGNC:15472 | RefSeq IDs: | NM_003888 |
Entrez Gene ID: | 8854 | Ensembl Gene ID: | ENSG00000128918 |
VEGA IDs: | OTTHUMG00000132624 | UniProt ID: | O94788 |
UCSC ID: | uc002aex.2 | OMIM ID: | 603687 |
Pubmed: | PMID9819382 | ||
CCDS IDs: | CCDSCCDS10163.1 CCDS CCDS10164.1 CCDS CCDS45266.1 |
Retinaldehyde dehydrogenase 2 (RALDH2) is an enzyme that in humans is encoded by the ALDH1A2 gene.
This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2011].
Function: Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity).
Products for ALDH1A2 gene
Catalog | Product Name | Application | Company |
GFS:E04681 | aldehyde dehydrogenase 1 family, member A2; ELISA kit | ELISA | n/a |
GFS:A04681 | aldehyde dehydrogenase 1 family, member A2; Anti | ANTIBODIES | n/a |
GFS:P04681 | aldehyde dehydrogenase 1 family, member A2; Protien | Protien | n/a |