Symbol: Name: ID: |
ADA adenosine deaminase GFS:7445 |
Gene name: | ADA |
Chromosome: | 20q13.12 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:87916 | Rat Genome Database ID: | RGD:2031 |
HGNC ID: | HGNC:186 | RefSeq IDs: | NM_000022 |
Entrez Gene ID: | 100 | Ensembl Gene ID: | |
VEGA IDs: | OTTHUMG00000033081 | UniProt ID: | P00813 |
UCSC ID: | uc002xmj.2 | OMIM ID: | 608958 |
Pubmed: | PMID6198240 PMID 6090454 | ||
CCDS IDs: | CCDSCCDS13335.1 |
Adenosine deaminase (also known as ADA) is an enzyme (EC 3.5.4.4) involved in purine metabolism. It is needed for the breakdown of adenosine from food and for the turnover of nucleic acids in tissues.
This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia. [provided by RefSeq, Jul 2008].
Function: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion.
Products for ADA gene
Catalog | Product Name | Application | Company |
GFS:E07445 | adenosine deaminase; ELISA kit | ELISA | n/a |
GFS:A07445 | adenosine deaminase; Anti | ANTIBODIES | n/a |
GFS:P07445 | adenosine deaminase; Protien | Protien | n/a |