Symbol: Name: ID: |
ACTN4 actinin, alpha 4 GFS:5704 |
Gene name: | ACTN4 |
Chromosome: | 19q13 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1890773 | Rat Genome Database ID: | RGD:61816 |
HGNC ID: | HGNC:166 | RefSeq IDs: | NM_004924 |
Entrez Gene ID: | Ensembl Gene ID: | ENSG00000130402 | |
VEGA IDs: | OTTHUMG00000137382 | UniProt ID: | O43707 |
UCSC ID: | uc002oja.1 | OMIM ID: | 604638 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS12518.1 |
Alpha-actinin-4 is a protein that in humans is encoded by the ACTN4 gene.
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation.
Products for ACTN4 gene
Catalog | Product Name | Application | Company |
GFS:E05704 | actinin, alpha 4; ELISA kit | ELISA | n/a |
GFS:A05704 | actinin, alpha 4; Anti | ANTIBODIES | n/a |
GFS:P05704 | actinin, alpha 4; Protien | Protien | n/a |