Symbol: Name: ID: |
ACTN1 actinin, alpha 1 GFS:5424 |
Gene name: | ACTN1 |
Chromosome: | 14q24.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2137706 | Rat Genome Database ID: | RGD:70907 |
HGNC ID: | HGNC:163 | RefSeq IDs: | NM_001102 |
Entrez Gene ID: | Ensembl Gene ID: | ENSG00000072110 | |
VEGA IDs: | UniProt ID: | P12814 | |
UCSC ID: | uc001xkm.2 | OMIM ID: | 102575 |
Pubmed: | PMID2349951 | ||
CCDS IDs: | CCDSCCDS9792.1 CCDS CCDS45129.1 CCDS CCDS45130.1 |
Alpha-actinin-1 is a protein that in humans is encoded by the ACTN1 gene.
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
Products for ACTN1 gene
Catalog | Product Name | Application | Company |
GFS:E05424 | actinin, alpha 1; ELISA kit | ELISA | n/a |
GFS:A05424 | actinin, alpha 1; Anti | ANTIBODIES | n/a |
GFS:P05424 | actinin, alpha 1; Protien | Protien | n/a |