Symbol: Name: ID: |
WISP2 WNT1 inducible signaling pathway protein 2 GFS:2531 |
Gene name: | WISP2 |
Chromosome: | 20q13.12 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CT58, CTGF-L, CCN5 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1328326 | Rat Genome Database ID: | RGD:621867 |
HGNC ID: | HGNC:12770 | RefSeq IDs: | NM_003881 |
Entrez Gene ID: | 8839 | Ensembl Gene ID: | ENSG00000064205 |
VEGA IDs: | OTTHUMG00000033071 | UniProt ID: | O76076 |
UCSC ID: | uc002xmp.2 | OMIM ID: | 603399 |
Pubmed: | PMID9843955 | ||
CCDS IDs: | CCDSCCDS13336.1 |
WNT1-inducible-signaling pathway protein 2 is a protein that in humans is encoded by the WISP2 gene.
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.
Products for WISP2 gene
Catalog | Product Name | Application | Company |
GFS:E02531 | WNT1 inducible signaling pathway protein 2; ELISA kit | ELISA | n/a |
GFS:A02531 | WNT1 inducible signaling pathway protein 2; Anti | ANTIBODIES | n/a |
GFS:P02531 | WNT1 inducible signaling pathway protein 2; Protien | Protien | n/a |