Symbol: Name: ID: |
WISP1 WNT1 inducible signaling pathway protein 1 GFS:2529 |
Gene name: | WISP1 |
Chromosome: | 8q24.22 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CCN4 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1197008 | Rat Genome Database ID: | RGD:69431 |
HGNC ID: | HGNC:12769 | RefSeq IDs: | NM_003882 |
Entrez Gene ID: | 8840 | Ensembl Gene ID: | ENSG00000104415 |
VEGA IDs: | UniProt ID: | O95388 | |
UCSC ID: | uc003yub.2 | OMIM ID: | 603398 |
Pubmed: | PMID9843955 | ||
CCDS IDs: | CCDSCCDS6371.1 CCDS CCDS6372.1 |
WNT1-inducible-signaling pathway protein 1 is a protein that in humans is encoded by the WISP1 gene.
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq].
Products for WISP1 gene
Catalog | Product Name | Application | Company |
GFS:E02529 | WNT1 inducible signaling pathway protein 1; ELISA kit | ELISA | n/a |
GFS:A02529 | WNT1 inducible signaling pathway protein 1; Anti | ANTIBODIES | n/a |
GFS:P02529 | WNT1 inducible signaling pathway protein 1; Protien | Protien | n/a |