| Symbol: Name: ID: |
TIA1 TIA1 cytotoxic granule-associated RNA binding protein GFS:1618 |
| Gene name: | TIA1 |
| Chromosome: | 2p13 |
| Previous Symbols: | |
| Previous Names: | TIA1 cytotoxic granule-associated RNA-binding protein |
| Aliases: | |
| Name Aliases: | T-cell-restricted intracellular antigen-1, |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:107914 | Rat Genome Database ID: | RGD:1305742 |
| HGNC ID: | HGNC:11802 | RefSeq IDs: | NM_022037 |
| Entrez Gene ID: | 7072 | Ensembl Gene ID: | ENSG00000116001 |
| VEGA IDs: | OTTHUMG00000129644 | UniProt ID: | P31483 |
| UCSC ID: | uc002sgj.3 | OMIM ID: | 603518 |
| Pubmed: | PMID8176212 PMID 12486009 | ||
| CCDS IDs: | CCDSCCDS1900.1 CCDS CCDS1901.1 | ||
The product encoded by TIA1 is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature. [provided by RefSeq].
Function: Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.
Products for TIA1 gene
| Catalog | Product Name | Application | Company |
| GFS:E01618 | TIA1 cytotoxic granule-associated RNA binding protein; ELISA kit | ELISA | n/a |
| GFS:A01618 | TIA1 cytotoxic granule-associated RNA binding protein; Anti | ANTIBODIES | n/a |
| GFS:P01618 | TIA1 cytotoxic granule-associated RNA binding protein; Protien | Protien | n/a |
