Symbol: Name: ID: |
TIAM2 T-cell lymphoma invasion and metastasis 2 GFS:1622 |
Gene name: | TIAM2 |
Chromosome: | 6q25 |
Previous Symbols: | |
Previous Names: | |
Aliases: | STEF |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1344338 | Rat Genome Database ID: | |
HGNC ID: | HGNC:11806 | RefSeq IDs: | NM_001010927 |
Entrez Gene ID: | 26230 | Ensembl Gene ID: | ENSG00000146426 |
VEGA IDs: | OTTHUMG00000015880 | UniProt ID: | Q8IVF5 |
UCSC ID: | uc003qqe.2 | OMIM ID: | 604709 |
Pubmed: | PMID10512681 | ||
CCDS IDs: | CCDSCCDS34558.1 CCDS CCDS34559.1 |
The TIAM2 gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq].
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA.
Products for TIAM2 gene
Catalog | Product Name | Application | Company |
GFS:E01622 | T-cell lymphoma invasion and metastasis 2; ELISA kit | ELISA | n/a |
GFS:A01622 | T-cell lymphoma invasion and metastasis 2; Anti | ANTIBODIES | n/a |
GFS:P01622 | T-cell lymphoma invasion and metastasis 2; Protien | Protien | n/a |