Symbol: Name: ID: |
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 GFS:6169 |
Gene name: | TAB2 |
Chromosome: | 6q25.1 |
Previous Symbols: | MAP3K7IP2 |
Previous Names: | mitogen-activated protein kinase kinase kinase 7 interacting protein 2 |
Aliases: | KIAA0733 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1915902 | Rat Genome Database ID: | RGD:1309527 |
HGNC ID: | HGNC:17075 | RefSeq IDs: | NM_015093 |
Entrez Gene ID: | 23118 | Ensembl Gene ID: | ENSG00000055208 |
VEGA IDs: | OTTHUMG00000015783 | UniProt ID: | Q9NYJ8 |
UCSC ID: | uc003qmj.2 | OMIM ID: | 605101 |
Pubmed: | PMID9872452 PMID 10882101 | ||
CCDS IDs: | CCDSCCDS5214.1 |
Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 is an enzyme that in humans is encoded by the MAP3K7IP2 gene.
The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development.
Products for TAB2 gene
Catalog | Product Name | Application | Company |
GFS:E06169 | TGF-beta activated kinase 1/MAP3K7 binding protein 2; ELISA kit | ELISA | n/a |
GFS:A06169 | TGF-beta activated kinase 1/MAP3K7 binding protein 2; Anti | ANTIBODIES | n/a |
GFS:P06169 | TGF-beta activated kinase 1/MAP3K7 binding protein 2; Protien | Protien | n/a |