Symbol: Name: ID: |
STAB1 stabilin 1 GFS:7473 |
Gene name: | STAB1 |
Chromosome: | 3p21.31 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0246, STAB-1, FEEL-1, CLEVER-1, FELE-1, FEX1 |
Name Aliases: | MS-1 antigen, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2178742 | Rat Genome Database ID: | |
HGNC ID: | HGNC:18628 | RefSeq IDs: | NM_015136 |
Entrez Gene ID: | 23166 | Ensembl Gene ID: | ENSG00000010327 |
VEGA IDs: | OTTHUMG00000158574 | UniProt ID: | Q9NY15 |
UCSC ID: | uc003dej.2 | OMIM ID: | 608560 |
Pubmed: | PMID11829752 PMID 12077138 | ||
CCDS IDs: | CCDSCCDS33768.1 |
Stabilin-1 is a protein that in humans is encoded by the STAB1 gene.
This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system.
Products for STAB1 gene
Catalog | Product Name | Application | Company |
GFS:E07473 | stabilin 1; ELISA kit | ELISA | n/a |
GFS:A07473 | stabilin 1; Anti | ANTIBODIES | n/a |
GFS:P07473 | stabilin 1; Protien | Protien | n/a |