Symbol: Name: ID: |
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 GFS:7043 |
Gene name: | TAB1 |
Chromosome: | 22q13.1 |
Previous Symbols: | MAP3K7IP1 |
Previous Names: | mitogen-activated protein kinase kinase kinase 7 interacting protein 1 |
Aliases: | |
Name Aliases: | TAK1-binding protein 1, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1913763 | Rat Genome Database ID: | |
HGNC ID: | HGNC:18157 | RefSeq IDs: | NM_006116 |
Entrez Gene ID: | 10454 | Ensembl Gene ID: | ENSG00000100324 |
VEGA IDs: | OTTHUMG00000151102 | UniProt ID: | Q15750 |
UCSC ID: | uc003axt.2 | OMIM ID: | 602615 |
Pubmed: | PMID8638164 PMID 10187861 | ||
CCDS IDs: | CCDSCCDS13992.1 CCDS CCDS13993.1 |
Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 is an enzyme that in humans is encoded by the MAP3K7IP1 gene.
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Function: May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
Products for TAB1 gene
Catalog | Product Name | Application | Company |
GFS:E07043 | TGF-beta activated kinase 1/MAP3K7 binding protein 1; ELISA kit | ELISA | n/a |
GFS:A07043 | TGF-beta activated kinase 1/MAP3K7 binding protein 1; Anti | ANTIBODIES | n/a |
GFS:P07043 | TGF-beta activated kinase 1/MAP3K7 binding protein 1; Protien | Protien | n/a |