Symbol: Name: ID: |
ARHGAP17 Rho GTPase activating protein 17 GFS:7111 |
Gene name: | ARHGAP17 |
Chromosome: | 16p12.2-p12.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | RICH1, FLJ10308, NADRIN, FLJ13219, WBP15 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1917747 | Rat Genome Database ID: | RGD:628767 |
HGNC ID: | HGNC:18239 | RefSeq IDs: | NM_001006634 |
Entrez Gene ID: | 55114 | Ensembl Gene ID: | ENSG00000140750 |
VEGA IDs: | UniProt ID: | Q68EM7 | |
UCSC ID: | uc002dnb.2 | OMIM ID: | 608293 |
Pubmed: | PMID10967100 PMID 11431473 | ||
CCDS IDs: | CCDSCCDS32408.1 CCDS CCDS32409.1 |
RICH1 is a GTPase-activating protein (GAP). GAPs stimulate the intrinsic GTP hydrolysis of small G proteins, such as RHOA (MIM 165390), RAC1 (MIM 602048), and CDC42 (MIM 116952).[supplied by OMIM, Apr 2004].
Function: Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activitor in vitro for RAC1.
Products for ARHGAP17 gene
Catalog | Product Name | Application | Company |
GFS:E07111 | Rho GTPase activating protein 17; ELISA kit | ELISA | n/a |
GFS:A07111 | Rho GTPase activating protein 17; Anti | ANTIBODIES | n/a |
GFS:P07111 | Rho GTPase activating protein 17; Protien | Protien | n/a |