Symbol: Name: ID: |
IKZF1 IKAROS family zinc finger 1 (Ikaros) GFS:2843 |
Gene name: | IKZF1 |
Chromosome: | 7pter-7qter |
Previous Symbols: | ZNFN1A1 |
Previous Names: | zinc finger protein, subfamily 1A, 1 (Ikaros) |
Aliases: | hIk-1, LyF-1, Hs.54452, IKAROS |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1342540 | Rat Genome Database ID: | RGD:1562979 |
HGNC ID: | HGNC:13176 | RefSeq IDs: | NM_006060 |
Entrez Gene ID: | 10320 | Ensembl Gene ID: | ENSG00000185811 |
VEGA IDs: | OTTHUMG00000155907 | UniProt ID: | Q13422 |
UCSC ID: | uc003tow.3 | OMIM ID: | 603023 |
Pubmed: | PMID1439790 PMID 7935426 | ||
CCDS IDs: |
DNA-binding protein Ikaros also known as Ikaros family zinc finger protein 1 is a protein that in humans is encoded by the IKZF1 gene.
This gene encodes a transcription factor that belongs to the family of zinc-finger DNA binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. All isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homodimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and contain the nuclear localization signal, resulting in members with and without DNA-binding properties. Only few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and thought to function as dominant negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq].
Products for IKZF1 gene
Catalog | Product Name | Application | Company |
GFS:E02843 | IKAROS family zinc finger 1 (Ikaros); ELISA kit | ELISA | n/a |
GFS:A02843 | IKAROS family zinc finger 1 (Ikaros); Anti | ANTIBODIES | n/a |
GFS:P02843 | IKAROS family zinc finger 1 (Ikaros); Protien | Protien | n/a |