Symbol: Name: ID: |
H2AFB2 H2A histone family, member B2 GFS:7171 |
Gene name: | H2AFB2 |
Chromosome: | Xq28 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:3644875 | Rat Genome Database ID: | RGD:1561666 |
HGNC ID: | HGNC:18298 | RefSeq IDs: | NM_001017991 |
Entrez Gene ID: | 474381 | Ensembl Gene ID: | ENSG00000198307 |
VEGA IDs: | OTTHUMG00000034292 | UniProt ID: | P0C5Z0 |
UCSC ID: | uc004fnh.2 | OMIM ID: | |
Pubmed: | |||
CCDS IDs: | CCDSCCDS35461.1 |
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the most centromeric copy which is in intron 22 of the F8 gene. [provided by RefSeq, Jul 2008].
Function: Atypical histone H2A which can replace conventional H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Nucleosomes containing this histone are less rigid and organize only 118 base pair of DNA instead of 147 in classical nucleosomes. They are associated with transcriptionally active chromatin and excluded form Barr bodies.
Products for H2AFB2 gene
Catalog | Product Name | Application | Company |
GFS:E07171 | H2A histone family, member B2; ELISA kit | ELISA | n/a |
GFS:A07171 | H2A histone family, member B2; Anti | ANTIBODIES | n/a |
GFS:P07171 | H2A histone family, member B2; Protien | Protien | n/a |