Symbol: Name: ID: |
BLMH bleomycin hydrolase GFS:514 |
Gene name: | BLMH |
Chromosome: | 17q11.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | BH |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1345186 | Rat Genome Database ID: | RGD:1304668 |
HGNC ID: | HGNC:1059 | RefSeq IDs: | NM_000386 |
Entrez Gene ID: | 642 | Ensembl Gene ID: | ENSG00000108578 |
VEGA IDs: | UniProt ID: | Q13867 | |
UCSC ID: | uc002hez.1 | OMIM ID: | 602403 |
Pubmed: | PMID9407121 PMID 9331073 | ||
CCDS IDs: | CCDSCCDS32604.1 |
Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity (By similarity)
Products for BLMH gene
Catalog | Product Name | Application | Company |
GFS:E00514 | bleomycin hydrolase; ELISA kit | ELISA | n/a |
GFS:A00514 | bleomycin hydrolase; Anti | ANTIBODIES | n/a |
GFS:P00514 | bleomycin hydrolase; Protien | Protien | n/a |