Symbol: Name: ID: |
PHAX phosphorylated adaptor for RNA export GFS:214 |
Gene name: | PHAX |
Chromosome: | 5q23.2 |
Previous Symbols: | RNUXA |
Previous Names: | RNA U, small nuclear RNA export adaptor (phosphorylation regulated) |
Aliases: | FLJ13193 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1891839 | Rat Genome Database ID: | RGD:708448 |
HGNC ID: | HGNC:10241 | RefSeq IDs: | NM_032177 |
Entrez Gene ID: | 51808 | Ensembl Gene ID: | ENSG00000164902 |
VEGA IDs: | OTTHUMG00000128945 | UniProt ID: | Q9H814 |
UCSC ID: | uc003kua.1 | OMIM ID: | 604924 |
Pubmed: | PMID10786834 | ||
CCDS IDs: | CCDSCCDS4138.1 |
A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA
Products for PHAX gene
Catalog | Product Name | Application | Company |
GFS:E00214 | phosphorylated adaptor for RNA export; ELISA kit | ELISA | n/a |
GFS:A00214 | phosphorylated adaptor for RNA export; Anti | ANTIBODIES | n/a |
GFS:P00214 | phosphorylated adaptor for RNA export; Protien | Protien | n/a |