Symbol: Name: ID: |
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 GFS:5871 |
Gene name: | EDEM3 |
Chromosome: | 1q25 |
Previous Symbols: | C1orf22 |
Previous Names: | chromosome 1 open reading frame 22 |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1914217 | Rat Genome Database ID: | RGD:1561496 |
HGNC ID: | HGNC:16787 | RefSeq IDs: | NM_025191 |
Entrez Gene ID: | 80267 | Ensembl Gene ID: | ENSG00000116406 |
VEGA IDs: | OTTHUMG00000035387 | UniProt ID: | Q9BZQ6 |
UCSC ID: | uc010pok.1 | OMIM ID: | 610214 |
Pubmed: | PMID15537790 PMID 15579471 | ||
CCDS IDs: | CCDSCCDS1363.2 |
ER degradation-enhancing alpha-mannosidase-like 3 is an enzyme that in humans is encoded by the EDEM3 gene.
Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM, Mar 2008].
Function: Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes. This process depends on mannose-trimming from the N-glycans. Seems to have alpha 1,2-mannosidase activity (By similarity).
Products for EDEM3 gene
Catalog | Product Name | Application | Company |
GFS:E05871 | ER degradation enhancer, mannosidase alpha-like 3; ELISA kit | ELISA | n/a |
GFS:A05871 | ER degradation enhancer, mannosidase alpha-like 3; Anti | ANTIBODIES | n/a |
GFS:P05871 | ER degradation enhancer, mannosidase alpha-like 3; Protien | Protien | n/a |