| Symbol: Name: ID: |
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 GFS:7775 |
| Gene name: | EDEM1 |
| Chromosome: | 3p26.1 |
| Previous Symbols: | |
| Previous Names: | |
| Aliases: | KIAA0212, EDEM |
| Name Aliases: | |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:2180139 | Rat Genome Database ID: | RGD:1563633 |
| HGNC ID: | HGNC:18967 | RefSeq IDs: | NM_014674 |
| Entrez Gene ID: | 9695 | Ensembl Gene ID: | ENSG00000134109 |
| VEGA IDs: | OTTHUMG00000154896 | UniProt ID: | Q92611 |
| UCSC ID: | uc003bqi.2 | OMIM ID: | 607673 |
| Pubmed: | PMID12610306 | ||
| CCDS IDs: | CCDSCCDS33686.1 | ||
ER degradation-enhancing alpha-mannosidase-like 1 is an enzyme that in humans is encoded by the EDEM1 gene.
Function: Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It lacks mannosidase activity.
Products for EDEM1 gene
| Catalog | Product Name | Application | Company |
| GFS:E07775 | ER degradation enhancer, mannosidase alpha-like 1; ELISA kit | ELISA | n/a |
| GFS:A07775 | ER degradation enhancer, mannosidase alpha-like 1; Anti | ANTIBODIES | n/a |
| GFS:P07775 | ER degradation enhancer, mannosidase alpha-like 1; Protien | Protien | n/a |
