Symbol: Name: ID: |
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 GFS:7775 |
Gene name: | EDEM1 |
Chromosome: | 3p26.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0212, EDEM |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2180139 | Rat Genome Database ID: | RGD:1563633 |
HGNC ID: | HGNC:18967 | RefSeq IDs: | NM_014674 |
Entrez Gene ID: | 9695 | Ensembl Gene ID: | ENSG00000134109 |
VEGA IDs: | OTTHUMG00000154896 | UniProt ID: | Q92611 |
UCSC ID: | uc003bqi.2 | OMIM ID: | 607673 |
Pubmed: | PMID12610306 | ||
CCDS IDs: | CCDSCCDS33686.1 |
ER degradation-enhancing alpha-mannosidase-like 1 is an enzyme that in humans is encoded by the EDEM1 gene.
Function: Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It lacks mannosidase activity.
Products for EDEM1 gene
Catalog | Product Name | Application | Company |
GFS:E07775 | ER degradation enhancer, mannosidase alpha-like 1; ELISA kit | ELISA | n/a |
GFS:A07775 | ER degradation enhancer, mannosidase alpha-like 1; Anti | ANTIBODIES | n/a |
GFS:P07775 | ER degradation enhancer, mannosidase alpha-like 1; Protien | Protien | n/a |