| Symbol: Name: ID: |
EDEM2 ER degradation enhancer, mannosidase alpha-like 2 GFS:5014 |
| Gene name: | EDEM2 |
| Chromosome: | 20q11.22 |
| Previous Symbols: | C20orf49, C20orf31 |
| Previous Names: | chromosome 20 open reading frame 31 |
| Aliases: | FLJ10783, bA4204.1 |
| Name Aliases: | |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:1915540 | Rat Genome Database ID: | RGD:1303074 |
| HGNC ID: | HGNC:15877 | RefSeq IDs: | NR_026728 |
| Entrez Gene ID: | 55741 | Ensembl Gene ID: | ENSG00000088298 |
| VEGA IDs: | OTTHUMG00000032322 | UniProt ID: | Q9BV94 |
| UCSC ID: | uc002xbo.2 | OMIM ID: | 610302 |
| Pubmed: | PMID15537790 PMID 15579471 | ||
| CCDS IDs: | CCDSCCDS13247.1 CCDS CCDS46592.1 | ||
ER degradation-enhancing alpha-mannosidase-like 2 is an enzyme that in humans is encoded by the EDEM2 gene.
In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in ERAD of glycoproteins (Mast et al., 2005 [PubMed 15537790]).[supplied by OMIM, Mar 2008].
Function: Involved in endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. It lacks mannosidase activity. Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle.
Products for EDEM2 gene
| Catalog | Product Name | Application | Company |
| GFS:E05014 | ER degradation enhancer, mannosidase alpha-like 2; ELISA kit | ELISA | n/a |
| GFS:A05014 | ER degradation enhancer, mannosidase alpha-like 2; Anti | ANTIBODIES | n/a |
| GFS:P05014 | ER degradation enhancer, mannosidase alpha-like 2; Protien | Protien | n/a |
