Symbol: Name: ID: |
CD8B CD8b molecule GFS:6163 |
Gene name: | CD8B |
Chromosome: | 2p12 |
Previous Symbols: | CD8B1 |
Previous Names: | CD8 antigen, beta polypeptide 1 (p37) |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88347 | Rat Genome Database ID: | RGD:2317 |
HGNC ID: | HGNC:1707 | RefSeq IDs: | NM_001178100 |
Entrez Gene ID: | 926 | Ensembl Gene ID: | ENSG00000172116 |
VEGA IDs: | OTTHUMG00000130264 | UniProt ID: | P10966 |
UCSC ID: | uc002ssa.2 | OMIM ID: | 186730 |
Pubmed: | PMID1541829 | ||
CCDS IDs: | CCDSCCDS1994.1 CCDS CCDS1995.1 CCDS CCDS42708.1 CCDS CCDS1997.1 |
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. (provided by RefSeq)
Function: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.
Products for CD8B gene
Catalog | Product Name | Application | Company |
GFS:E06163 | CD8b molecule; ELISA kit | ELISA | n/a |
GFS:A06163 | CD8b molecule; Anti | ANTIBODIES | n/a |
GFS:P06163 | CD8b molecule; Protien | Protien | n/a |