Symbol: Name: ID: |
CD40 CD40 molecule, TNF receptor superfamily member 5 GFS:1730 |
Gene name: | CD40 |
Chromosome: | 20q12-q13.2 |
Previous Symbols: | TNFRSF5 |
Previous Names: | tumor necrosis factor receptor superfamily, member 5 |
Aliases: | p50, Bp50 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88336 | Rat Genome Database ID: | RGD:619830 |
HGNC ID: | HGNC:11919 | RefSeq IDs: | NM_001250 |
Entrez Gene ID: | 958 | Ensembl Gene ID: | |
VEGA IDs: | OTTHUMG00000033053 | UniProt ID: | P25942 |
UCSC ID: | uc002xrg.1 | OMIM ID: | 109535 |
Pubmed: | PMID7687385 PMID 2998589 | ||
CCDS IDs: | CCDSCCDS13393.1 CCDS CCDS13394.1 |
CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq].
Products for CD40 gene
Catalog | Product Name | Application | Company |
GFS:E01730 | CD40 molecule, TNF receptor superfamily member 5; ELISA kit | ELISA | n/a |
GFS:A01730 | CD40 molecule, TNF receptor superfamily member 5; Anti | ANTIBODIES | n/a |
GFS:P01730 | CD40 molecule, TNF receptor superfamily member 5; Protien | Protien | n/a |