Symbol: Name: ID: |
CD27 CD27 molecule GFS:1734 |
Gene name: | CD27 |
Chromosome: | 12p13 |
Previous Symbols: | TNFRSF7 |
Previous Names: | tumor necrosis factor receptor superfamily, member 7 |
Aliases: | S152, Tp55 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88326 | Rat Genome Database ID: | RGD:1560499 |
HGNC ID: | HGNC:11922 | RefSeq IDs: | NM_001242 |
Entrez Gene ID: | 939 | Ensembl Gene ID: | ENSG00000139193 |
VEGA IDs: | UniProt ID: | P26842 | |
UCSC ID: | uc001qod.2 | OMIM ID: | 186711 |
Pubmed: | PMID2442250 PMID 8530100 | ||
CCDS IDs: | CCDSCCDS8545.1 |
CD27 is a tumor necrosis factor receptor. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
Products for CD27 gene
Catalog | Product Name | Application | Company |
GFS:E01734 | CD27 molecule; ELISA kit | ELISA | n/a |
GFS:A01734 | CD27 molecule; Anti | ANTIBODIES | n/a |
GFS:P01734 | CD27 molecule; Protien | Protien | n/a |