Symbol: Name: ID: |
CD86 CD86 molecule GFS:6143 |
Gene name: | CD86 |
Chromosome: | 3q21 |
Previous Symbols: | CD28LG2 |
Previous Names: | CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:101773 | Rat Genome Database ID: | RGD:628714 |
HGNC ID: | HGNC:1705 | RefSeq IDs: | NM_006889 |
Entrez Gene ID: | 942 | Ensembl Gene ID: | ENSG00000114013 |
VEGA IDs: | OTTHUMG00000159482 | UniProt ID: | P42081 |
UCSC ID: | uc003eet.2 | OMIM ID: | 601020 |
Pubmed: | PMID7513726 | ||
CCDS IDs: | CCDSCCDS3009.1 CCDS CCDS43138.1 |
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011].
Function: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
Products for CD86 gene
Catalog | Product Name | Application | Company |
GFS:E06143 | CD86 molecule; ELISA kit | ELISA | n/a |
GFS:A06143 | CD86 molecule; Anti | ANTIBODIES | n/a |
GFS:P06143 | CD86 molecule; Protien | Protien | n/a |