Symbol: Name: ID: |
CD79A CD79a molecule, immunoglobulin-associated alpha GFS:6068 |
Gene name: | CD79A |
Chromosome: | 19q13.2 |
Previous Symbols: | IGA |
Previous Names: | CD79A antigen (immunoglobulin-associated alpha) |
Aliases: | MB-1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:101774 | Rat Genome Database ID: | RGD:1598036 |
HGNC ID: | HGNC:1698 | RefSeq IDs: | NM_001783 |
Entrez Gene ID: | 973 | Ensembl Gene ID: | |
VEGA IDs: | UniProt ID: | P11912 | |
UCSC ID: | uc002orv.2 | OMIM ID: | 112205 |
Pubmed: | PMID1538135 | ||
CCDS IDs: | CCDSCCDS12589.1 CCDS CCDS46088.1 |
CD79a molecule, immunoglobulin-associated alpha, also known as mb-1, is a human gene.
The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Function: Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B cells.
Products for CD79A gene
Catalog | Product Name | Application | Company |
GFS:E06068 | CD79a molecule, immunoglobulin-associated alpha; ELISA kit | ELISA | n/a |
GFS:A06068 | CD79a molecule, immunoglobulin-associated alpha; Anti | ANTIBODIES | n/a |
GFS:P06068 | CD79a molecule, immunoglobulin-associated alpha; Protien | Protien | n/a |