Symbol: Name: ID: |
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain GFS:6059 |
Gene name: | CD74 |
Chromosome: | 5q31-q33 |
Previous Symbols: | DHLAG |
Previous Names: | CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) |
Aliases: | |
Name Aliases: | HLA-DR-gamma, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:96534 | Rat Genome Database ID: | RGD:2313 |
HGNC ID: | HGNC:1697 | RefSeq IDs: | NM_001025158 |
Entrez Gene ID: | 972 | Ensembl Gene ID: | ENSG00000019582 |
VEGA IDs: | UniProt ID: | P04233 | |
UCSC ID: | uc003lsc.2 | OMIM ID: | 142790 |
Pubmed: | PMID6324166 PMID 3001652 | ||
CCDS IDs: | CCDSCCDS34276.1 CCDS CCDS47308.1 CCDS CCDS47309.1 |
HLA class II histocompatibility antigen gamma chain also known as HLA-DR antigens-associated invariant chain or CD74 (Cluster of Differentiation 74), is a protein that in humans is encoded by the CD74 gene.
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].
Products for CD74 gene
Catalog | Product Name | Application | Company |
GFS:E06059 | CD74 molecule, major histocompatibility complex, class II invariant chain; ELISA kit | ELISA | n/a |
GFS:A06059 | CD74 molecule, major histocompatibility complex, class II invariant chain; Anti | ANTIBODIES | n/a |
GFS:P06059 | CD74 molecule, major histocompatibility complex, class II invariant chain; Protien | Protien | n/a |