Symbol: Name: ID: |
CD59 CD59 molecule, complement regulatory protein GFS:5975 |
Gene name: | CD59 |
Chromosome: | 11p13 |
Previous Symbols: | MIC11, MIN1, MSK21, MIN2, MIN3 |
Previous Names: | CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344), "CD59 antigen, complement regulatory protein" |
Aliases: | 16.3A5, EJ16, EJ30, EL32, G344, p18-20 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1888996 | Rat Genome Database ID: | RGD:2311 |
HGNC ID: | HGNC:1689 | RefSeq IDs: | NM_000611 |
Entrez Gene ID: | 966 | Ensembl Gene ID: | |
VEGA IDs: | UniProt ID: | P13987 | |
UCSC ID: | uc001mus.3 | OMIM ID: | 107271 |
Pubmed: | PMID7691713 | ||
CCDS IDs: | CCDSCCDS7886.1 |
Protectin, a complement regulatory protein, also known as CD59, or MIRL (membrane inhibitor of reactive lysis) is a human gene and protein.
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008].
Function: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
Function: The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.
Products for CD59 gene
Catalog | Product Name | Application | Company |
GFS:E05975 | CD59 molecule, complement regulatory protein; ELISA kit | ELISA | n/a |
GFS:A05975 | CD59 molecule, complement regulatory protein; Anti | ANTIBODIES | n/a |
GFS:P05975 | CD59 molecule, complement regulatory protein; Protien | Protien | n/a |