Symbol: Name: ID: |
CD47 CD47 molecule GFS:5905 |
Gene name: | CD47 |
Chromosome: | 3q13.1-q13.2 |
Previous Symbols: | MER6 |
Previous Names: | CD47 antigen (Rh-related antigen, integrin-associated signal transducer) |
Aliases: | IAP, OA3 |
Name Aliases: | antigen identified by monoclonal antibody 1D8, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:96617 | Rat Genome Database ID: | RGD:2308 |
HGNC ID: | HGNC:1682 | RefSeq IDs: | NM_001777 |
Entrez Gene ID: | 961 | Ensembl Gene ID: | ENSG00000196776 |
VEGA IDs: | OTTHUMG00000044216 | UniProt ID: | Q08722 |
UCSC ID: | uc003dwt.1 | OMIM ID: | 601028 |
Pubmed: | PMID8294396 PMID 2277087 | ||
CCDS IDs: | CCDSCCDS43125.1 CCDS CCDS43126.1 |
CD47 (Cluster of Differentiation 47) is a protein that in humans is encoded by the CD47 gene.
This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010].
Function: Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.
Products for CD47 gene
Catalog | Product Name | Application | Company |
GFS:E05905 | CD47 molecule; ELISA kit | ELISA | n/a |
GFS:A05905 | CD47 molecule; Anti | ANTIBODIES | n/a |
GFS:P05905 | CD47 molecule; Protien | Protien | n/a |