Symbol: Name: ID: |
CD4 CD4 molecule GFS:5865 |
Gene name: | CD4 |
Chromosome: | 12pter-p12 |
Previous Symbols: | |
Previous Names: | CD4 antigen (p55) |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88335 | Rat Genome Database ID: | RGD:2306 |
HGNC ID: | HGNC:1678 | RefSeq IDs: | NM_000616 |
Entrez Gene ID: | 920 | Ensembl Gene ID: | ENSG00000010610 |
VEGA IDs: | UniProt ID: | P01730 | |
UCSC ID: | uc001qqv.1 | OMIM ID: | 186940 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS8562.1 |
CD4 (cluster of differentiation 4) is a glycoprotein expressed on the surface of T helper cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 (after the OKT4 monoclonal antibody that reacted with it) before being named CD4 in 1984. In humans, the CD4 protein is encoded by the CD4 gene.
This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010].
Function: Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Products for CD4 gene
Catalog | Product Name | Application | Company |
GFS:E05865 | CD4 molecule; ELISA kit | ELISA | n/a |
GFS:A05865 | CD4 molecule; Anti | ANTIBODIES | n/a |
GFS:P05865 | CD4 molecule; Protien | Protien | n/a |