Symbol: Name: ID: |
CD247 CD247 molecule GFS:5855 |
Gene name: | CD247 |
Chromosome: | 1q22-q25 |
Previous Symbols: | CD3Z |
Previous Names: | CD3z antigen, zeta polypeptide (TiT3 complex), "CD247 antigen" |
Aliases: | CD3H, CD3Q |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88334 | Rat Genome Database ID: | RGD:2305 |
HGNC ID: | HGNC:1677 | RefSeq IDs: | NM_000734 |
Entrez Gene ID: | 919 | Ensembl Gene ID: | |
VEGA IDs: | OTTHUMG00000034593 | UniProt ID: | P20963 |
UCSC ID: | uc001gei.3 | OMIM ID: | 186780 |
Pubmed: | PMID2974162 | ||
CCDS IDs: | CCDSCCDS1260.1 CCDS CCDS1261.1 |
T-cell surface glycoprotein CD3 zeta chain also known as T-cell receptor T3 zeta chain or CD247 (Cluster of Differentiation 247) is a protein that in humans is encoded by the CD247 gene.
The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function: Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
Products for CD247 gene
Catalog | Product Name | Application | Company |
GFS:E05855 | CD247 molecule; ELISA kit | ELISA | n/a |
GFS:A05855 | CD247 molecule; Anti | ANTIBODIES | n/a |
GFS:P05855 | CD247 molecule; Protien | Protien | n/a |