Symbol: Name: ID: |
CD22 CD22 molecule GFS:5541 |
Gene name: | CD22 |
Chromosome: | 19q13.1 |
Previous Symbols: | |
Previous Names: | CD22 antigen |
Aliases: | SIGLEC-2, SIGLEC2 |
Name Aliases: | sialic acid binding Ig-like lectin 2 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88322 | Rat Genome Database ID: | RGD:1311610 |
HGNC ID: | HGNC:1643 | RefSeq IDs: | NM_001185099 |
Entrez Gene ID: | 933 | Ensembl Gene ID: | ENSG00000012124 |
VEGA IDs: | OTTHUMG00000070560 | UniProt ID: | P20273 |
UCSC ID: | uc010edt.2 | OMIM ID: | 107266 |
Pubmed: | PMID8496602 PMID 1691828 | ||
CCDS IDs: | CCDSCCDS12457.1 |
CD22 or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins.
Function: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Products for CD22 gene
Catalog | Product Name | Application | Company |
GFS:E05541 | CD22 molecule; ELISA kit | ELISA | n/a |
GFS:A05541 | CD22 molecule; Anti | ANTIBODIES | n/a |
GFS:P05541 | CD22 molecule; Protien | Protien | n/a |