Symbol: Name: ID: |
CD2 CD2 molecule GFS:5505 |
Gene name: | CD2 |
Chromosome: | 1p13 |
Previous Symbols: | SRBC |
Previous Names: | CD2 antigen (p50), sheep red blood cell receptor |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88320 | Rat Genome Database ID: | RGD:2297 |
HGNC ID: | HGNC:1639 | RefSeq IDs: | NM_001767 |
Entrez Gene ID: | 914 | Ensembl Gene ID: | ENSG00000116824 |
VEGA IDs: | OTTHUMG00000022750 | UniProt ID: | P06729 |
UCSC ID: | uc001egu.3 | OMIM ID: | 186990 |
Pubmed: | PMID2437578 | ||
CCDS IDs: | CCDSCCDS889.1 |
CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells. It has also been called T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, erythrocyte receptor and rosette receptor.
CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
Products for CD2 gene
Catalog | Product Name | Application | Company |
GFS:E05505 | CD2 molecule; ELISA kit | ELISA | n/a |
GFS:A05505 | CD2 molecule; Anti | ANTIBODIES | n/a |
GFS:P05505 | CD2 molecule; Protien | Protien | n/a |