Symbol: Name: ID: |
CD1E CD1e molecule GFS:5496 |
Gene name: | CD1E |
Chromosome: | 1q22-q23 |
Previous Symbols: | |
Previous Names: | CD1E antigen, e polypeptide, "CD1e antigen" |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | Rat Genome Database ID: | ||
HGNC ID: | HGNC:1638 | RefSeq IDs: | NM_001042583 |
Entrez Gene ID: | 913 | Ensembl Gene ID: | ENSG00000158488 |
VEGA IDs: | OTTHUMG00000017515 | UniProt ID: | P15812 |
UCSC ID: | uc001fse.2 | OMIM ID: | 188411 |
Pubmed: | PMID10948205 | ||
CCDS IDs: | CCDSCCDS41417.1 CCDS CCDS41418.1 CCDS CCDS41419.1 CCDS CCDS41420.1 CCDS CCDS41421.1 CCDS CCDS41422.1 |
T-cell surface glycoprotein CD1e, membrane-associated is a protein that in humans is encoded by the CD1E gene.
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined. [provided by RefSeq, Jun 2010].
Function: T-cell surface glycoprotein CD1e, soluble is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active.
Products for CD1E gene
Catalog | Product Name | Application | Company |
GFS:E05496 | CD1e molecule; ELISA kit | ELISA | n/a |
GFS:A05496 | CD1e molecule; Anti | ANTIBODIES | n/a |
GFS:P05496 | CD1e molecule; Protien | Protien | n/a |