Symbol: Name: ID: |
CD163 CD163 molecule GFS:5432 |
Gene name: | CD163 |
Chromosome: | 12p13 |
Previous Symbols: | |
Previous Names: | CD163 antigen |
Aliases: | M130, MM130 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2135946 | Rat Genome Database ID: | RGD:1310382 |
HGNC ID: | HGNC:1631 | RefSeq IDs: | NM_004244 |
Entrez Gene ID: | 9332 | Ensembl Gene ID: | ENSG00000177575 |
VEGA IDs: | UniProt ID: | Q86VB7 | |
UCSC ID: | uc001qsz.3 | OMIM ID: | 605545 |
Pubmed: | PMID10403791 PMID 8370408 | ||
CCDS IDs: | CCDSCCDS8578.1 |
CD163 (Cluster of Differentiation 163) is a human protein encoded by the CD163 gene.
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011].
Function: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells
Function: After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
Products for CD163 gene
Catalog | Product Name | Application | Company |
GFS:E05432 | CD163 molecule; ELISA kit | ELISA | n/a |
GFS:A05432 | CD163 molecule; Anti | ANTIBODIES | n/a |
GFS:P05432 | CD163 molecule; Protien | Protien | n/a |