Symbol: Name: ID: |
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 GFS:3931 |
Gene name: | ABCC11 |
Chromosome: | 16q12 |
Previous Symbols: | |
Previous Names: | |
Aliases: | MRP8 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | Rat Genome Database ID: | ||
HGNC ID: | HGNC:14639 | RefSeq IDs: | NM_032583 |
Entrez Gene ID: | 85320 | Ensembl Gene ID: | ENSG00000121270 |
VEGA IDs: | OTTHUMG00000133146 | UniProt ID: | Q96J66 |
UCSC ID: | uc002efg.1 | OMIM ID: | 607040 |
Pubmed: | PMID11483364 PMID 11435397 | ||
CCDS IDs: | CCDSCCDS10732.1 CCDS CCDS10733.1 |
ATP-binding cassette transporter sub-family C member 11 is a protein that in humans is encoded by the ABCC11 gene.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008].
Function: Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax.
Products for ABCC11 gene
Catalog | Product Name | Application | Company |
GFS:E03931 | ATP-binding cassette, sub-family C (CFTR/MRP), member 11; ELISA kit | ELISA | n/a |
GFS:A03931 | ATP-binding cassette, sub-family C (CFTR/MRP), member 11; Anti | ANTIBODIES | n/a |
GFS:P03931 | ATP-binding cassette, sub-family C (CFTR/MRP), member 11; Protien | Protien | n/a |