Symbol: Name: ID: |
ARID5B AT rich interactive domain 5B (MRF1-like) GFS:6441 |
Gene name: | ARID5B |
Chromosome: | 10q11.22 |
Previous Symbols: | |
Previous Names: | |
Aliases: | FLJ21150, MRF2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2175912 | Rat Genome Database ID: | RGD:1311735 |
HGNC ID: | HGNC:17362 | RefSeq IDs: | NM_032199 |
Entrez Gene ID: | 84159 | Ensembl Gene ID: | ENSG00000150347 |
VEGA IDs: | OTTHUMG00000018298 | UniProt ID: | Q14865 |
UCSC ID: | uc001jlt.1 | OMIM ID: | 608538 |
Pubmed: | PMID11483573 PMID 11478881 | ||
CCDS IDs: | CCDSCCDS31208.1 |
AT-rich interactive domain-containing protein 5B is a protein that in humans is encoded by the ARID5B gene.
This gene encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded protein forms a histone H3K9Me2 demethylase complex with PHD finger protein 2 and regulates the transcription of target genes involved in adipogenesis and liver development. This gene also plays a role in cell growth and differentiation of B-lymphocyte progenitors, and single nucleotide polymorphisms in this gene are associated with acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011].
Function: DNA-binding protein that binds to the 5'-AATA[CT]-3' core sequence. Probably acts as a transcription regulator. Represses the cytomegalovirus enhancer. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may act as a regulator of smooth muscle cell differentiation and proliferation. May be involved in lipid stores.
Products for ARID5B gene
Catalog | Product Name | Application | Company |
GFS:E06441 | AT rich interactive domain 5B (MRF1-like); ELISA kit | ELISA | n/a |
GFS:A06441 | AT rich interactive domain 5B (MRF1-like); Anti | ANTIBODIES | n/a |
GFS:P06441 | AT rich interactive domain 5B (MRF1-like); Protien | Protien | n/a |