Symbol: Name: ID: |
ARID1B AT rich interactive domain 1B (SWI1-like) GFS:6932 |
Gene name: | ARID1B |
Chromosome: | 6q25.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA1235, ELD/OSA1, p250R, BAF250b, DAN15, 6A3-5 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1926129 | Rat Genome Database ID: | RGD:708504 |
HGNC ID: | HGNC:18040 | RefSeq IDs: | NM_017519 |
Entrez Gene ID: | 57492 | Ensembl Gene ID: | ENSG00000049618 |
VEGA IDs: | OTTHUMG00000015890 | UniProt ID: | Q8NFD5 |
UCSC ID: | uc003qqn.2 | OMIM ID: | |
Pubmed: | |||
CCDS IDs: | CCDSCCDS5251.1 |
AT-rich interactive domain-containing protein 1B is a protein that in humans is encoded by the ARID1B gene.
Function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically.
Products for ARID1B gene
Catalog | Product Name | Application | Company |
GFS:E06932 | AT rich interactive domain 1B (SWI1-like); ELISA kit | ELISA | n/a |
GFS:A06932 | AT rich interactive domain 1B (SWI1-like); Anti | ANTIBODIES | n/a |
GFS:P06932 | AT rich interactive domain 1B (SWI1-like); Protien | Protien | n/a |