Symbol: Name: ID: |
ARID1A AT rich interactive domain 1A (SWI-like) GFS:1018 |
Gene name: | ARID1A |
Chromosome: | 1p36.1-p35 |
Previous Symbols: | C1orf4, SMARCF1 |
Previous Names: | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily f, member 1, "AT rich interactive domain 1A (SWI- like)" |
Aliases: | B120, P270, C10rf4, BAF250, BAF250a |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1935147 | Rat Genome Database ID: | RGD:1310500 |
HGNC ID: | HGNC:11110 | RefSeq IDs: | NM_006015 |
Entrez Gene ID: | 8289 | Ensembl Gene ID: | ENSG00000117713 |
VEGA IDs: | OTTHUMG00000004004 | UniProt ID: | O14497 |
UCSC ID: | uc001bmv.1 | OMIM ID: | 603024 |
Pubmed: | PMID9630625 PMID 9434167 | ||
CCDS IDs: | CCDSCCDS285.1 CCDS CCDS44091.1 |
AT-rich interactive domain-containing protein 1A is a protein that in humans is encoded by the ARID1A gene. This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Products for ARID1A gene
Catalog | Product Name | Application | Company |
GFS:E01018 | AT rich interactive domain 1A (SWI-like); ELISA kit | ELISA | n/a |
GFS:A01018 | AT rich interactive domain 1A (SWI-like); Anti | ANTIBODIES | n/a |
GFS:P01018 | AT rich interactive domain 1A (SWI-like); Protien | Protien | n/a |