Symbol: Name: ID: |
ARL6 ADP-ribosylation factor-like 6 GFS:2870 |
Gene name: | ARL6 |
Chromosome: | 3q11.2 |
Previous Symbols: | BBS3 |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1927136 | Rat Genome Database ID: | RGD:1305535 |
HGNC ID: | HGNC:13210 | RefSeq IDs: | NM_032146 |
Entrez Gene ID: | 84100 | Ensembl Gene ID: | ENSG00000113966 |
VEGA IDs: | OTTHUMG00000159189 | UniProt ID: | Q9H0F7 |
UCSC ID: | uc003drv.2 | OMIM ID: | 608845 |
Pubmed: | PMID15258860 PMID 15314642 | ||
CCDS IDs: | CCDSCCDS2928.1 |
ADP-ribosylation factor-like protein 6 is a protein that in humans is encoded by the ARL6 gene.
The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. ARF proteins are important regulators of cellular traffic and are the founding members of an expanding family of homologous proteins and genomic sequences. They depart from other small GTP-binding proteins by a unique structural device that implements front-back communication from the N-terminus to the nucleotide-binding site. Studies of the mouse ortholog of this protein suggest an involvement in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been described. [provided by RefSeq].
Function: Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization.
Products for ARL6 gene
Catalog | Product Name | Application | Company |
GFS:E02870 | ADP-ribosylation factor-like 6; ELISA kit | ELISA | n/a |
GFS:A02870 | ADP-ribosylation factor-like 6; Anti | ANTIBODIES | n/a |
GFS:P02870 | ADP-ribosylation factor-like 6; Protien | Protien | n/a |