Symbol: Name: ID: |
PARL presenilin associated, rhomboid-like GFS:7125 |
Gene name: | PARL |
Chromosome: | 3q27.3 |
Previous Symbols: | PSARL |
Previous Names: | |
Aliases: | PRO2207, PSARL1, RHBDS1 |
Name Aliases: | rhomboid 7 homolog 1 (Drosophila) |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1277152 | Rat Genome Database ID: | RGD:1306191 |
HGNC ID: | HGNC:18253 | RefSeq IDs: | NM_001037639 |
Entrez Gene ID: | 55486 | Ensembl Gene ID: | ENSG00000175193 |
VEGA IDs: | OTTHUMG00000156890 | UniProt ID: | Q9H300 |
UCSC ID: | uc003fmd.2 | OMIM ID: | 607858 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS3248.1 CCDS CCDS33897.1 |
Presenilins-associated rhomboid-like protein, mitochondrial is a protein that in humans is encoded by the PARL gene .
This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Function: Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain.
Products for PARL gene
Catalog | Product Name | Application | Company |
GFS:E07125 | presenilin associated, rhomboid-like; ELISA kit | ELISA | n/a |
GFS:A07125 | presenilin associated, rhomboid-like; Anti | ANTIBODIES | n/a |
GFS:P07125 | presenilin associated, rhomboid-like; Protien | Protien | n/a |