Symbol: Name: ID: |
XYLT2 xylosyltransferase II GFS:4723 |
Gene name: | XYLT2 |
Chromosome: | 17q21.33 |
Previous Symbols: | |
Previous Names: | |
Aliases: | XT-II, PXYLT2 |
Name Aliases: | protein xylosyltransferase 2 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2444797 | Rat Genome Database ID: | RGD:619765 |
HGNC ID: | HGNC:15517 | RefSeq IDs: | NM_022167 |
Entrez Gene ID: | 64132 | Ensembl Gene ID: | ENSG00000015532 |
VEGA IDs: | UniProt ID: | Q9H1B5 | |
UCSC ID: | uc002iqo.2 | OMIM ID: | 608125 |
Pubmed: | PMID11099377 | ||
CCDS IDs: | CCDSCCDS11563.1 |
Xylosyltransferase 2 is an enzyme that in humans is encoded by the XYLT2 gene.
The protein encoded by this gene is an isoform of xylosyltransferase, which belongs to a family of glycosyltransferases. This enzyme transfers xylose from UDP-xylose to specific serine residues of the core protein and initiates the biosynthesis of glycosaminoglycan chains in proteoglycans including chondroitin sulfate, heparan sulfate, heparin and dermatan sulfate. The enzyme activity, which is increased in scleroderma patients, is a diagnostic marker for the determination of sclerotic activity in systemic sclerosis. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Probably catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes (By similarity). Its enzyme activity has not been demonstrated.
Products for XYLT2 gene
Catalog | Product Name | Application | Company |
GFS:E04723 | xylosyltransferase II; ELISA kit | ELISA | n/a |
GFS:A04723 | xylosyltransferase II; Anti | ANTIBODIES | n/a |
GFS:P04723 | xylosyltransferase II; Protien | Protien | n/a |